Chelsea Handler: Reese Witherspoon "Is Driving Me Crazy!"

Reese Witherspoon is one of Chelsea Handler's closest celebrity pals, but in a clip from Sunday's all new episode of After Lately, the 35-year-old Oscar winner becomes her biggest nightmare.

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The problem: Witherspoon enlists the help of Handler's writing staff to prepare a speech, but her perky demeanor grates on Handler, 36. "She is driving me crazy!" Handler complains behind Witherspoon's back. "She is so awful."

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The comedienne and bestselling author ignores her employees' polite suggestion to confront Witherspoon, explaining: "What am I supposed to do? I'm gonna go tell Reese Witherspoon that I think she sucks? She's a mess!"

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Will Witherspoon catch Handler badmouthing her? Watch the clip (above) to find out and tune in for an all-new episode of After Lately Sunday at 11 p.m. EST on E!.

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